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People's Hospital (Shenzhen, China) between May 2016 and DecemberĢ018. Were admitted to the Neonatal Intensive Care Unit of Longhua
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The research subjects were 140 neonates with ALI who Serum inflammatory cytokines in neonates with ALI. Was designed to explore the efficacy of IVIG and its effects on Surfactants and few studies have reported treatment with IVIG Neonates mainly focuses on mechanical ventilation and pulmonary Important role and are involved in the occurrence and developmentĬurrently, research into the treatment of ALI in Studies have suggested that inflammatory responses play an Structure by binding with receptors on endothelial cells in lungĬapillaries and alveolar epithelial cells. These inflammatoryĬytokines may damage pulmonary alveoli and pulmonary capillary (IL-6) and tumor necrosis factor-α (TNF-α). Lung injury can activate a variety of inflammatory cells to releaseĪ large number of inflammatory cytokines, including interleukin-6 An inflammatory cascade reaction triggered by However, few studies have been conducted on the application of IVIG Treatment of various autoimmune and inflammatory diseases ( 6, 7), suchĪs Kawasaki disease, sepsis and viral encephalitis ( 8-10). Immunoglobulin G (IgG) antibodies, which has an immunosuppressiveĪnd anti-inflammatory effect. Product extracted from healthy human blood, with abundant Intravenous immunoglobulin (IVIG) is a plasma More effective and safe treatment would be highly beneficial for Primary underlying diseases, and prognosis in patients is poor Ventilation and treatment methods for secondary organ injury and Treatment of ALI, though it is usually treated using mechanical Despite progress in management ofĪRDS in pediatric intensive care units, ARDS still has a highĬurrently, there is no specific method in clinical practice for the Intensive care units, and 8-10% of patients with ARDS require Acute respiratory distress syndromeĪRDS accounts for approximately 1-4% of all admissions to pediatric Lead to multiple organ dysfunction syndrome, multiple system organįailure and other life-threatening complications ( 2). The primary clinical manifestations ofĪLI are progressive hypoxemia and respiratory distress. When they have infection, hypoxia or shock ( 1). The results of the present study indicate that IVIG may improve pulmonary gas exchange, shorten the course of disease and reduce the inflammatory response in neonates with ALI.Īcute lung injury (ALI) is characterized by high The 30‑day survival rate in the high IL‑6 and high TNF‑α expression COG was lower than that in the low IL‑6 and low TNF‑α expression COG (both P<0.05). After treatment, PaO 2 and PaO 2/FiO2 were significantly higher and mechanical ventilation and hospitalization time were reduced in the STG in comparison with the COG (all P0.05). The patients were divided into high and low cytokine expression groups based on their mean expression levels of serum IL‑6 and TNF‑α before treatment.
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The Kaplan‑Meier method was used to analyze the survival of the patients, including their survival for 30 days after treatment. ELISA was used to determine the levels of interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α) in the patients before treatment and at 12, 24 and 36 h after treatment. The arterial partial pressure of oxygen (PaO 2), PaO 2/fraction of inspired oxygen (FIO2), mechanical ventilation time and hospitalization time were compared between the two groups. The COG patients were treated routinely, whereas patients in the STG were administered IVIG in addition to the standard treatment received by the COG. The research subjects were 140 neonates with ALI who were evenly distributed into a control group (COG) and a study group (STG). The present study aimed to explore the efficacy of intravenous immunoglobulin (IVIG) injection in neonates with acute lung injury (ALI) and assess its effects on serum inflammatory cytokine levels.